People with schizophrenia have more rare genetic mutations

. Buy Natural Soap online chizophrenia is a common, complex disorder that appears to arise from a number of factors, some of which are genetic. http://allegra-opinion.blogspot.com Avapro (Irbesartan) with no Rx Now, a new study of the genetic mutations associated with schizophrenia has deepened our understanding of its genetic structure. The DNA screening study found that patients with schizophrenia had more rare variants of genes that code for proteins than people not affected by the condition. The international study, led by the University of California Los Angeles (UCLA), is published in the journal Nature Communications. There, the researchers describe how after screening for hundreds of thousands of genetic variants in people with and without schizophrenia, they found certain types - rare mutations that code for proteins - occur more frequently in people with the condition. First author Dr. Viagra Soft (Sildenafil Citrate) without prescription Loes Olde Loohuis, of UCLA s Center for Neurobehavioral Genetics, says: "While we cannot point to specific mutations that play a causal role in schizophrenia, we show that schizophrenia patients collectively have more of these mutations than unaffected individuals." Mutations in genes that code for proteins play a key role in the development of the brain before birth, notes senior author Roel Ophoff, a professor in psychiatry and human genetics at UCLA, who adds: "Our finding further supports the hypothesis that schizophrenia is a disorder that may originate during the early stages of brain development." Schizophrenia is a common disorder characterized by hallucinations, delusions and disorganization, that can significantly impair quality of life for patients and their families. Buy Advair Diskus (Salmeterol+Fluticasone) with no prescription In the US, around 2-3 million people have the condition. Rare coding variants contribute to complex genetic architecture of schizophrenia Fast facts about schizophrenia Schizophrenia is a condition that affects thinking, feeling and behavior and causes people to have abnormal experiences The condition will affect around 1 in every 100 people in their lifetime Contrary to what many believe, people with schizophrenia are rarely violent - they are more likely to be victims of violence by others. Find out more about schizophrenia For the study, the team used a commercially available DNA screening tool to search for 250,000 coding variants in 1,042 schizophrenia patients from the Netherlands and 961 unaffected individuals. A coding variant is where a gene or sequence of DNA that contains instructions for making a protein is slightly altered, thus raising the chance that the associated protein may cause malfunction in the cell in which it is made. The results of the DNA screening showed that the patients with schizophrenia had more of the variants than patients without schizophrenia. The researchers confirmed these findings in another study group of more than 13,000 people with and without schizophrenia. Prof. Buy Colgout with free prescription Ophoff says even though we know there is a large genetic component in schizophrenia, we do not know enough about the underlying biology, and concludes: "Our research shows that rare coding variants throughout the human genome also contribute to this complex genetic architecture." In discussing their results, the authors also note that the genes containing rare coding variants "significantly overlap with genes expressed in fetal brain highlighting the potential involvement of neurodevelopment" in the causes of schizophrenia. The National Institute of Mental Health funded the research. This work follows news of another piece of research that Medical News Today reported recently that offers strong evidence of a neurological cause of schizophrenia. Buy Ceftin (Cefuroxime) without prescription Writing in the journal Neuron, a team from the University of Cardiff in the UK describes how they found schizophrenia mutations interfere with chemical signaling in the brain. Written by Catharine Paddock PhD