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NEW YORK--(BUSINESS WIRE)--Houlihan Lokey (NYSE:HLI), the international investment bank, today announced that Fedora Baloiu has joined the firm as Head of the Biopharmaceutical practice in the firm’s Healthcare Group. Buy Azulfidine (Sulfasalazine) with no prescription Ms. Vesicare (Solifenacin) Baloiu will be focusing on advising pharma, biotech and biopharma services and technology clients globally. Buy Combivent (Ipratropium bromide / Albuterol sulfate) with free Rx She is based in New York, reporting to Mark Francis, Managing Director and Head of the Healthcare Group. Ms. About Fucidin with no Rx Baloiu joins from Goldman Sachs, where she has spent the last nine years in the Healthcare group within the Investment Banking Division in New York, focusing on pharmaceutical and biotech clients. Gestanin (Progestogen) with no Rx While at Goldman, Ms. Buy Diarrhea and IBS online Baloiu worked on multiple M&A and financing transactions in the biopharma space and spent 18 months in the London office. http://future-pharmaceuticals.blogspot.com Prior to Goldman Sachs, she worked in Bain & Company’s Consumer and Healthcare Group, providing strategic management consulting services to clients throughout Europe. Over the course of her career, Ms. Baloiu has advised on M&A and financing transactions with an aggregate value in excess of $65 billion. "We are delighted that Fedora is joining our healthcare team and we look forward to collaborating with her to create significant success for clients in the biopharmaceutical sector," said Mr. Francis. "Her client relationships and depth of expertise in biopharmaceutical sector is tremendously valuable in both U.S. and Europe, where we see a sustained high level of M&A activity," he added. "Houlihan Lokey s Healthcare Group has had tremendous success in providing world class advice to clients and assisting them in achieving market-leading outcomes. The Healthcare team has deep relationships with strategics, financial sponsors, and financing sources and provides a broad range of services and superior advice resulting in compelling solutions for clients,” said Ms. Baloiu. "I am excited to join a market-leading Healthcare team and I look forward to working with my colleagues to continue the momentum the Group has achieved to date. I expect the Biopharma and related services to continue the tremendous growth experienced in recent years and I am eager to build upon such opportunities with a leading team," she continued. Houlihan Lokey has approximately 1,000 employees across 20 global locations and is a long-term leader in the mid-cap M&A market. With over 30 dedicated banking professionals, Houlihan Lokey’s Healthcare Group is among the largest in financial services. Following Ms. Baloiu’s hire, the Group’s coverage capabilities span every vertical across the healthcare sector. In 2014, the Group ranked #1 for US transactions under $1 billion, according to Thomson Reuters. Ms. Baloiu holds a B.A. in Finance from Bocconi University and an MBA from Columbia Business School. About Houlihan Lokey Houlihan Lokey is an international investment bank with expertise in mergers and acquisitions, capital markets, financial restructuring, valuation, and strategic consulting. The firm serves corporations, institutions, and governments worldwide with offices in the United States, Europe, and the Asia-Pacific region. Independent advice and intellectual rigor are hallmarks of our commitment to client success across our advisory services. Houlihan Lokey is ranked as the No. 1 M&A advisor for U.S. transactions under $5 billion, the No. 1 global restructuring advisor, and the No. 1 M&A fairness opinion advisor for U.S. transactions over the past 10 years, according to Thomson Reuters. For more information, please visit .hl.com.

Il Comitato europeo per i prodotti medicinali per uso umano (CHMP) esprime un parere positivo per Genvoya® (elvitegravir, cobicistat, emtricitabina e tenofovir alafenamide), il regime monocompressa di Gilead...

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About Zestoretic (Lisinopril-Hctz) with no Rx I dati contenuti nella domanda di autorizzazione alla commercializzazione avvalorano l uso del regime in individui adulti e adolescenti na"ive al trattamento, in adulti virologicamente soppressi che hanno cambiato regime e in adulti con danni renali da lievi a moderati. La raccomandazione del CHMP sar`a ora sottoposta all esame della Commissione Europea, che `e l ente preposto all approvazione dei farmaci per l uso nei 28 Paesi dell’Unione Europea. About Professional Pack-20 () Se tale autorizzazione sar`a rilasciata, Genvoya sarebbe il primo regime monocompressa di Gilead contenente TAF. 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Enumeral to Present at the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference and BioPharm America 2015

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Acute Ischemic Stroke Pipeline Review, H2 2015 - 17 Companies & 22 Drug Profiles

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Global Mu Antagonists Pipeline Insights Review 2015

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World Hemophillia A Pipeline Insights Review 2015

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XenoPort to Release Second Quarter Financial Results on August 5, 2015

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Global Mixed Dyslipidemia Pipeline Insights Report 2015

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First real-life trial for oral cholera vaccine successful in Bangladesh

The first real-life trial of the oral cholera vaccine Shanchol has been deemed safe to use and viable for protection against the disease. Desogen (Desogestrel-Ethinyl Estradiol) with no Rx Results reveal that severe life-threatening cases of cholera was reduced by nearly 40% among those vaccinated. Rocaltrol (Calcitriol) with no Rx Cholera a bacterial illness that typically enters the body through contaminated water or food. The study, published in The Lancet, examined the drug s effectiveness in urban Bangladesh where the disease is endemic. Buy Desogen (Desogestrel / Ethinyl estradiol) without prescription The findings represent a huge step toward controlling outbreaks and developing effective mass vaccination programs. The drug is one of two internationally licensed cholera vaccines currently available. D4T pill with no Rx Cholera vaccines are not a new development and have been used to protect travelers from Western countries for more than a decade, but never have they been used for widespread control of the disease in an endemic region. Although the vaccine is effective, easy to administer and relatively inexpensive to produce, it has never been tested on a mass group in real-life conditions until now. Buy Amaryl (Glimepiride) with free prescription The study included almost 27,000 residents aged one year and older from the urban slums of Mirpur, in the city of Dhaka. Buy Puffy Eye Treatment online The area poses an extremely high risk of cholera infection in the area due to overcrowding and poor sanitation. http://anti-infectives-opinion.blogspot.com Researchers conducted a double-blind, cluster-randomized, placebo-controlled trial. Residents were prescribed one of the following: An oral cholera vaccine An oral cholera vaccine plus behavioral change program to improve hand-washing and to provide clean drinking water No intervention at all. The vaccine was administrated in two doses 14 days apart through routine government health services, and the publicity campaign for vaccination was well accepted by the local community. However, just over half of the residents in the two intervention groups received the complete number of doses. Despite this, the vaccination showed promising results. The overall incidence of severely dehydrating cholera fell by 37% after two years in the vaccination group and by 45% when used in combination with the hand washing and clean drinking water program. Analysis of individual protection showed the vaccine gave 53% protection against cholera during the two-year follow-up. There were no serious adverse effects from the vaccine; the majority of reactions were mild or moderate. The most common were acute watery diarrhea, vomiting, abdominal pain and fever. Lead author Dr. Firduausi Qadri from the International Centre for Diarrhea Disease Research, Bangladesh, hopes the findings act as a springboard for future development: "Our findings show that a routine oral cholera vaccination program in cholera-endemic countries could substantially reduce the burden of disease and greatly contribute to cholera control efforts. The vaccine is cheap: two doses cost US $3.7, around a third of the price of the other licensed vaccine Dukoral." Only part of the solution Worldwide, cholera affects 3-5 million people, and over 1 billion are estimated to be at risk of disease. The disease remains a danger in more than 50 countries where it is endemic such as Bangladesh. Although the results of the study are promising, Dr. Qadri believes a vaccine is only part of the solution. She explains: "Ultimately, the key to controlling cholera is clean water and adequate sanitation, which half the developing world (around 2.5 billion people) lack, but this remains a rather difficult reality for the world s poorest nations as well as those affected by climate change, war and natural disaster." Earlier this year, the Nepal Earthquake caused millions to be at risk of a cholera outbreak in the aftermath of the disaster. Maureen O Leary and Kim Mulholland from the London School of Hygiene & Tropical Medicine, echo Dr. Qadri s comments, saying a vaccine should "not supersede efforts to reduce risky behaviors." Cholera is a diarrheal illness caused by the bacteria Vibrio cholera and most commonly enters the human ecosystem through contaminated water or food. If untreated, the disease can have high fatality rates, especially among young children and babies. The cholera epidemic in parts of Africa has been ongoing for more than 30 years, due to inadequate sanitation and water treatment systems. Written by Peter Lam

Tours of Iraq and Afghanistan highlight those soldiers at highest suicide risk

. http://cardiobloodreview.wordpress.com Researchers have analyzed data from 9,791 Army personnel who attempted suicide during the wars in Afghanistan and Iraq, identifying risk factors for enlisted soldiers and officers. Officer ranks in the Army were at much lower risk for suicide than regular enlisted soldiers. According to the study in JAMA Psychiatry, from 2004 through 2009, the Army experienced the longest sustained increase in suicide rates relative to the other US military branches (Navy, Marines and Air Force). About Cordarone (Amiodarone) with no Rx Nonfatal attempts rose sharply in line with an increase in fatal attempts. Dr. Sporanox (Itraconazole) with no Rx Robert Ursano, of the Uniformed Services University of the Health Sciences in Bethesda, MD, and coauthors identified risk factors among the data. About Septilin () without prescription Enlisted soldiers had higher odds for a suicide attempt if they were: Female Had entered the Army at age 25 years or older Were currently 29 years old or younger Had not completed high school Were in their first 4 years of service Had a mental health diagnosis during the previous month. The research finds that female enlisted soldiers are more than twice as likely as male enlisted soldiers to attempt suicide in spite of accounting for only 13.7% of the active-duty regular Army - so may be considered for risk assessment interventions, say the authors. The researchers estimates showed that soldiers were more likely to get into a suicidal state than their managing officers. Enlisted women had nearly 13 times the risk of female officers for a suicide attempt; and enlisted soldiers who entered the Army at 25 years or older had more than 16 times the risk of officers in the same age group. The authors conclude: "Enlisted soldiers in their first tour of duty account for most medically documented suicide attempts. Cyclogyl with no Rx Risk is particularly high among soldiers with a recent mental health diagnosis. A concentration of risk strategy that incorporates factors such as sex, rank, age, length of service, deployment status and mental health diagnosis into targeted prevention programs may have the greatest effect on population health within the US Army." Dr. Artane (Trihexyphenidyl) without Rx Ursano and team used data on documented suicide attempts in active-duty US Army members during the wars in Afghanistan and Iraq from the Army Study to Assess Risk and Resilience in Service members (Army STARRS). Higher ranks at lower risk While enlisted soldiers constituted 83.5% of active-duty regular Army soldiers, they accounted for almost all cases of suicide attempt (98.6%, or 9,650 cases). This equated to an overall rate of 377 per 100,000 person-years during the study period. Officer ranks (both commissioned and warrant) accounted for 16.5% of the regular Army but only 1.4% of suicide attempts (141 cases), equating to an overall rate of 27.9 per 100,000 person-years. The peak time for suicide risk in enlisted soldiers was the second month of duty, after which the risk fell as length of service increased. Buy Pomegranate online The groups showing lower likelihood of a suicide attempt were: Black, Hispanic or Asian race or ethnicity Currently deployed enlisted soldiers (as compared with other enlisted soldiers). The study authors make this recommendation: "Future studies should examine suicide attempt risk in the context of other military characteristics (for example, military occupational specialty, number of previous deployments, history of promotion and demotion) and mental health indicators (for example, number and types of psychiatric diagnoses, treatment history)." Written by Markus MacGill

People with schizophrenia have more rare genetic mutations

. Buy Natural Soap online chizophrenia is a common, complex disorder that appears to arise from a number of factors, some of which are genetic. http://allegra-opinion.blogspot.com Avapro (Irbesartan) with no Rx Now, a new study of the genetic mutations associated with schizophrenia has deepened our understanding of its genetic structure. The DNA screening study found that patients with schizophrenia had more rare variants of genes that code for proteins than people not affected by the condition. The international study, led by the University of California Los Angeles (UCLA), is published in the journal Nature Communications. There, the researchers describe how after screening for hundreds of thousands of genetic variants in people with and without schizophrenia, they found certain types - rare mutations that code for proteins - occur more frequently in people with the condition. First author Dr. Viagra Soft (Sildenafil Citrate) without prescription Loes Olde Loohuis, of UCLA s Center for Neurobehavioral Genetics, says: "While we cannot point to specific mutations that play a causal role in schizophrenia, we show that schizophrenia patients collectively have more of these mutations than unaffected individuals." Mutations in genes that code for proteins play a key role in the development of the brain before birth, notes senior author Roel Ophoff, a professor in psychiatry and human genetics at UCLA, who adds: "Our finding further supports the hypothesis that schizophrenia is a disorder that may originate during the early stages of brain development." Schizophrenia is a common disorder characterized by hallucinations, delusions and disorganization, that can significantly impair quality of life for patients and their families. Buy Advair Diskus (Salmeterol+Fluticasone) with no prescription In the US, around 2-3 million people have the condition. Rare coding variants contribute to complex genetic architecture of schizophrenia Fast facts about schizophrenia Schizophrenia is a condition that affects thinking, feeling and behavior and causes people to have abnormal experiences The condition will affect around 1 in every 100 people in their lifetime Contrary to what many believe, people with schizophrenia are rarely violent - they are more likely to be victims of violence by others. Find out more about schizophrenia For the study, the team used a commercially available DNA screening tool to search for 250,000 coding variants in 1,042 schizophrenia patients from the Netherlands and 961 unaffected individuals. A coding variant is where a gene or sequence of DNA that contains instructions for making a protein is slightly altered, thus raising the chance that the associated protein may cause malfunction in the cell in which it is made. The results of the DNA screening showed that the patients with schizophrenia had more of the variants than patients without schizophrenia. The researchers confirmed these findings in another study group of more than 13,000 people with and without schizophrenia. Prof. Buy Colgout with free prescription Ophoff says even though we know there is a large genetic component in schizophrenia, we do not know enough about the underlying biology, and concludes: "Our research shows that rare coding variants throughout the human genome also contribute to this complex genetic architecture." In discussing their results, the authors also note that the genes containing rare coding variants "significantly overlap with genes expressed in fetal brain highlighting the potential involvement of neurodevelopment" in the causes of schizophrenia. The National Institute of Mental Health funded the research. This work follows news of another piece of research that Medical News Today reported recently that offers strong evidence of a neurological cause of schizophrenia. Buy Ceftin (Cefuroxime) without prescription Writing in the journal Neuron, a team from the University of Cardiff in the UK describes how they found schizophrenia mutations interfere with chemical signaling in the brain. Written by Catharine Paddock PhD

Why are doctors so guilty of working while sick?

The results of a small survey published online by JAMA Pediatrics suggest that many clinicians show up for work when sick, despite knowing that this could put patients at increased risk. Previous studies have shown that sick health care workers are the main source of influenza, Staphylococcus aureus and Norovirus within health care facilities. Infections occurring while a patient is being treated can significantly exacerbate their illness and also lead to increased costs. Anafranil (Clomipramine) without prescription Previous studies have shown that sick health care workers are the main source of influenza, Staphylococcus aureus and Norovirus within health care facilities. Newborn babies and people with compromised immune systems are known to be especially at risk from these infections, which can prove fatal. To find out why physicians and advanced practice clinicians continue to work while sick, despite the risks, researchers at the Children s Hospital of Philadelphia, PA, polled workers at their hospital in an anonymous survey. A total of 280 attending physicians and 256 advanced practice clinicians - including registered nurse practitioners, physician assistants, clinical nurse specialists, certified registered nurse anesthetists and certified nurse midwives - completed the survey. The vast majority of respondents - 95.3% - agreed that patients are put at risk by health care providers working while sick. Xalatan (Latanoprost) However, 83.1% of respondents reported working while sick at least once in the past year, and 9.3% reported working while sick at least five times. Physicians and advanced practice clinicians reported the following reasons why they continued to work while sick: Not wanting to let colleagues down (98.7%) Staffing concerns (94.9%) Not wanting to let patients down (92.5%) Fear of being ostracized by colleagues (64%) Concerns about the continuity of care (63.8%). Resourcing, stigma and culture of soldiering on contribute to problem Analyzing the comments provided by respondents, the researchers found three main areas that drive health care providers to continue working while ill. Glucovance (Metformin/Glyburide) with no Rx These are logistical or resource problems with arranging for someone to cover their work, a culture of reporting for work unless extremely ill, and ambiguity over what symptoms make someone too sick to work. The authors write: "The study illustrates the complex social and logistic factors that cause this behavior. Buy Clopidogrel without prescription These results may inform efforts to design systems at our hospital to provide support for attending physicians and [advanced practice clinicians] and help them make the right choice to keep their patients and colleagues safe while caring for themselves." Dr. Buy Cialis Professional (Tadalafil) with no prescription Jeffrey R. Buy Molds & Dust online Starke, of the Baylor College of Medicine, Houston, TX, and Dr. http://doctor-answers.blogspot.com/ Mary Anne Jackson, University of Missouri-Kansas City School of Medicine write in an accompanying editorial that a culture change is required in order to decrease the stigma associated with not turning up for work when ill. To do this, they argue that health care workers require a "more equitable system of sick leave." "Identifying solutions to prioritize patient safety must factor in workplace demands and variability in patient census and emphasize flexibility," they add. "Also essential is clarity from occupational health and infection control departments to identify what constitutes being too sick to work." Written by David McNamee

Universal flu vaccine steps closer

Flu vaccines in the US are made to target a small number of viral strains based on public health experts predictions. About Levitra Super Force (Vardenafil + Dapoxetine) without Rx Scientists hope that, one day, a universal flu vaccine will be developed that will be effective against all strains, and the findings of a new study may take researchers one step closer to this goal. Influenza is dangerous in adults aged over 65, who are most likely to have serious complications from the illness. The study, published in Cell, found that chemical modifications to a specific region in antibodies could be used to improve current flu vaccines. "We believe these results may represent a preliminary step toward a universal flu vaccine, one that is effective against a broad range of the flu viruses," states senior author Jeffrey Ravetch, head of the Leonard Wagner Laboratory of Molecular Genetics and Immunology at the Rockefeller University, New York. Vaccines in the US are typically formulated to target H1 and H3 influenza A viruses along with influenza B strains predicted by experts to be prevalent during the coming flu season. Buy Antabuse (Disulfiram) without Rx If the experts predictions are inaccurate, however, then the vaccines are rendered ineffective. Just this January, the Centers for Disease Control and Prevention (CDC) reported that this season s flu vaccine was only 23% effective across all age groups, due to a large proportion of this season s viruses being "drift variants." "While the conventional flu vaccine protects only against specific strains, usually three of them, our experiments show that by including modified antibodies within the vaccine it may be possible to elicit broad protection against many strains simultaneously," explains Ravetch. Influenza can be a dangerous illness - particularly in adults over the age of 65 and people with other health conditions. Furoxone (Furazolidone) without Rx The American Lung Association state that 90% of deaths from influenza occur in adults older than 65. It is a difficult virus for scientists to target with vaccines due to the wide variety of strains that exist, with new strains emerging regularly. About Cifran without prescription Because of how elusive the virus can be, a universal vaccine represents a dream goal for scientists and has been the focus of many research projects. The new study revolves around a new strategy involving the Fc region of antibodies - the region that connects with immune cells. Buy Dostinex (Cabergoline) The researchers, led by Taia Wang and Jad Maamary, already knew that modifying the Fc region affected how the antibodies interacted with immune cells, and so the team set out to investigate how changes to the region might improve an immune response. Efficacy of improved vaccine: no small accomplishment Healthy volunteers were vaccinated with a seasonal flu vaccine containing an inactivated strain of the H1N1 virus - also known as swine flu. Buy Liquid Multi Vitamin online Using blood samples, the researchers tracked how the participants immune systems responded, looking for chemical modifications to antibodies against a surface protein. Around a week later, the researchers noticed an increase in the number of sialylated antibodies present. http://doctoranswers.wordpress.com Sialic acid is a molecule crucial to signaling, meaning that the presence of these antibodies indicated a positive response to the vaccine. Experiments on cell cultures and mice revealed that sialylated Fc regions bind to a receptor protein called CD23 on specific immune cells called B cells. In turn, CD23 activates another receptor known as FcyRIIB that discourages B cells from producing low-affinity antibodies. In short, sialylated Fc regions lead to the activation of B cells producing the highest affinity antibodies. The researchers found that this higher affinity resulted in broad protection against influenza viruses from the H1 subtype (to which H1N1 belongs). Using this discovery, the researchers modified the H1N1 vaccine by adding sialylated antibodies against the virus protein. The new and improved vaccine was then tested on mice. "When we immunized mice with just the H1 protein from one strain or with the sialylated complexes containing the same viral protein, we found both offered equal protection against the same strain of flu," explains Maamary. "However, when we exposed them to strains expressing different versions of the H1 protein, only the sialylated immunizations offered protection." Wang believes the new mechanism they have uncovered could potentially be utilized to reduce the rates of morbidity and mortality attributable to seasonal influenza virus infections. "We are now looking into applying this strategy toward improving existing vaccines; ideally, this would result in a vaccine that provides lifelong immunity against flu infections," she states. Earlier this year, Medical News Today reported on a study suggesting that a newly discovered class of antibodies could lead to a universal flu vaccine "within 5 years." Written by James McIntosh

Genetic variation influences effectiveness of anti-diabetic drug

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NEW YORK--(BUSINESS WIRE)--Pfizer Inc. Buy Uroxatral (Alfuzosin) without prescription announced today that the United States Food and Drug Administration (FDA) accepted for review Pfizer’s new drug application (NDA) for XELJANZ® (tofacitinib citrate) 11 mg once daily modified release tablets for the treatment of moderate to severe rheumatoid arthritis (RA) in patients who have had an inadequate response or intolerance to methotrexate (MTX). Claritin (Loratadine) The FDA has provided an anticipated Prescription Drug User Fee Act (PDUFA) action date in February 2016 for the NDA. The NDA for XELJANZ 11 mg once daily modified release is based on data from a clinical pharmacology program designed to demonstrate equivalence in key pharmacokinetic parameters to XELJANZ 5 mg twice daily. “This filing underscores our commitment to helping advance patient care and our goal of providing innovative solutions for patients with RA,” said Rory O’Connor, MD, senior vice president and head of Global Medical Affairs, Global Innovative Pharmaceuticals Business, Pfizer Inc. Buy Garcinia Cambogia () without prescription “If approved, it would bring us one step closer to offering the first and only once-daily oral Janus kinase inhibitor treatment for those living with moderate to severe RA who have had an inadequate response or intolerance to methotrexate.” As the developer of XELJANZ, Pfizer is a leader in the research of this new class of medications. About Carbidopa with no Rx XELJANZ is approved in 40 countries around the world for the treatment of moderate to severe rheumatoid arthritis (RA). Hair Loss Cream () without Rx In the United States, XELJANZ has a boxed warning for serious infections and malignancies. About the XELJANZ Clinical Development Program Pfizer is committed to building on the science and understanding of JAK inhibition and XELJANZ through a robust clinical development program in a range of immune-mediated inflammatory conditions in the areas of rheumatology, dermatology and gastroenterology. Buy Hand Cream online A supplemental new drug application for XELJANZ 10 mg and 5 mg tablets twice daily is currently under review with the FDA for the treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy. http://doctorconsult.wordpress.com The benefit:risk profile of XELJANZ in RA has been studied in approximately 6,200 patients in the global clinical development program for XELJANZ in moderate to severe RA. XELJANZ U.S. Label Information XELJANZ is a prescription medicine called a Janus kinase (JAK) inhibitor. The recommended dose is 5 mg twice-daily (BID). XELJANZ is used to treat adults with moderately to severely active rheumatoid arthritis in which methotrexate did not work well. XELJANZ may be used as a single agent or in combination with MTX or other non-biologic disease-modifying antirheumatic drugs (DMARDs). Use of XELJANZ in combination with biologic DMARDs or potent immunosuppressants, such as azathioprine and cyclosporine is not recommended. It is not known if XELJANZ is safe and effective in people with hepatitis B or C. XELJANZ is not for people with severe liver problems. It is not known if XELJANZ is safe and effective in children. Important Safety Information XELJANZ can lower the ability of the immune system to fight infections. Some people have serious infections while taking XELJANZ, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Healthcare providers should test patients for TB before starting XELJANZ, and monitor them closely for signs and symptoms of TB and other infections during treatment. People should not start taking XELJANZ if they have any kind of infection unless their healthcare provider tells them it is okay. People may be at a higher risk of developing shingles. XELJANZ may increase the risk of certain cancers by changing the way the immune system works. Lymphoma and other cancers, including skin cancers, have happened in patients taking XELJANZ. The risks and benefits of treatment should be considered prior to initiating XELJANZ in patients with chronic or recurrent infection; who have been exposed to tuberculosis; with a history of a serious or an opportunistic infection; who have resided or traveled in areas of endemic tuberculosis or endemic mycoses; or with underlying conditions that may predispose them to infection. Viral reactivation, including cases of herpes virus reactivation (e.g., herpes zoster), was observed in clinical studies with XELJANZ. Use of live vaccines should be avoided concurrently with XELJANZ. Update immunizations in agreement with current immunization guidelines prior to initiating XELJANZ therapy. Some people who have taken XELJANZ with certain other medicines to prevent kidney transplant rejection have had a problem with certain white blood cells growing out of control (Epstein Barr virus-associated post-transplant lymphoproliferative disorder). Some people taking XELJANZ get tears in their stomach or intestines. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate. Patients should tell their healthcare provider right away if they have fever and stomach-area pain that does not go away, or a change in bowel habits. XELJANZ should be used with caution in patients who may be at increased risk for gastrointestinal perforation (e.g., patients with a history of diverticulitis). XELJANZ can cause changes in certain lab test results including low blood cell counts, increases in certain liver tests, and increases in cholesterol levels. Healthcare providers should do blood tests before starting patients on XELJANZ and while they are taking XELJANZ, to check for these side effects. Normal cholesterol levels are important to good heart health. Healthcare providers may stop XELJANZ treatment because of changes in blood cell counts or liver test results. Use of XELJANZ in patients with severe hepatic impairment is not recommended. Patients should tell their healthcare providers if they plan to become pregnant or are pregnant. It is not known if XELJANZ will harm an unborn baby. To monitor the outcomes of pregnant women exposed to XELJANZ, a registry has been established. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by calling 1-877-311-8972. Patients should tell their healthcare providers if they plan to breastfeed or are breastfeeding. Patients and their healthcare provider should decide if they will take XELJANZ or breastfeed. They should not do both. In carriers of the hepatitis B or C virus (viruses that affect the liver), the virus may become active while using XELJANZ. Healthcare providers may do blood tests before and during treatment with XELJANZ. Common side effects include upper respiratory tract infections (common cold, sinus infections), headache, diarrhea, and nasal congestion, sore throat, and runny nose (nasopharyngitis). Please click the direct link to the full prescribing information for XELJANZ, including boxed warning and Medication Guide: labeling.pfizer.com/ShowLabeling.aspx?id=959. About Rheumatoid Arthritis Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that causes a range of symptoms, including stiffness and swelling in the joints,1,2 particularly those in the hands, feet and knees.3 Although the exact cause of RA is unknown,1 it is considered to be an autoimmune disease, because the immune system in people with RA mistakes the body’s healthy tissues for a threat and attacks them.3 Some people are at increased risk of developing RA, including people with a family history of RA, smokers and women.3 Three times as many women are affected by RA compared to men.2 RA affects approximately 23.7 million people4 worldwide and 1.6 million people in the United States.5,6 It can develop at any time during adulthood, but it usually occurs between 40 and 70 years of age.2 Pfizer Inc.: Working together for a healthier world® At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products. Our global portfolio includes medicines and vaccines as well as many of the world s best-known consumer health care products. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world s premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us. To learn more, please visit us at .pfizer.com. DISCLOSURE NOTICE: The information contained in this release is as of July 2, 2015. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. This release contains forward-looking information about XELJANZ, including its potential benefits and a potential once daily formulation of XELJANZ that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the possibility of unfavorable clinical trial results, including unfavorable new clinical data and additional analyses of existing clinical data; whether and when any applications for XELJANZ may be filed with regulatory authorities in any other jurisdictions; whether and when the FDA may approve the NDA or the supplemental new drug application and whether and when regulatory authorities in other jurisdictions in which such applications are pending or will be submitted may approve such applications, which will depend on the assessment by such regulatory authorities of the benefit-risk profile suggested by the totality of the efficacy and safety information submitted; decisions by regulatory authorities regarding labeling and other matters that could affect the availability or commercial potential of XELJANZ; and competitive developments. A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2014 and in its subsequent reports on Form 10-Q, including in the sections thereof captioned “Risk Factors” and “Forward-Looking Information and Factors That May Affect Future Results”, as well as in its subsequent reports on Form 8-K, all of which are filed with the SEC and available at .sec.gov and .pfizer.com. 1 Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet. 2001; 358:903-911. 2 Medline Plus, “Rheumatoid Arthritis” Accessed 11 October 2011. Available at .nlm.nih.gov/medlineplus/ency/article/000431.htm. 3 Mayo Clinic, “Rheumatoid Arthritis.” Accessed 14 September 2011. Available at .mayoclinic.com/health/rheumatoid-arthritis/DS00020/DSECTION=risk-factors. 4 World Health Organization, “The Global Burden of Disease, 2004 Update.” Accessed 13 March 2012. Available at .who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf. 5 Sacks, J., Lou, Y., Helmick, C. Prevalence of Specific Types of Arthritis and Other Rheumatic Conditions in the Ambulatory Health Care System in the United States 2001-2005. Arthritis Care and Research. 2010. 62(4): 460- 464. 6 Howden, L., Meyer, J., 2010 U.S. Census Bureau results --- U.S. Census Bureau, 2010 Census Summary File 1.

Faulty cellular 'garbage disposal' implicated in Alzheimer's

. http://doctorconsult.wordpress.com ne of the hallmarks of Alzheimer s disease is deposits of beta-amyloid - a faulty protein - in the brain. Buy Uroxatral (Alfuzosin) without prescription Surrounding these deposits or plaques are abnormally high numbers of lysosomes, tiny specialized systems that digest and dispose of cellular garbage. Lysosomes - in magenta - accumulate near amyloid plaques. Alzheimer s disease is the most common form of dementia. Claritin (Loratadine) It affects the part of the brain that controls thought, memory and language. The disease begins with mild memory loss and progresses to the point where the person affected struggles to carry on a conversation and respond to what is happening around them. According to the Centers for Disease Control and Prevention, in 2013, as many as 5 million Americans aged 65 years or older had Alzheimer s disease, and the number is expected to rise to 13.8 million by 2050. When scientists first found - around 50 years ago - that beta-amyloid deposits in the brains of people with Alzheimer s disease were surrounded by massive accumulations of lysosomes, they assumed they were there to help degrade and clear away the faulty protein. Now, a new study from Yale University of New Haven, CT, suggests not only is it not as straightforward as this, but the opposite could be happening. The Yale team found that the lysosomes surrounding the deposits of beta-amyloid are faulty, and instead of working against Alzheimer s progression, may even be contributing to it. The researchers report their findings in the Proceedings of the National Academy of Sciences. They suggest the discovery could lead to new types of treatment that correct the faulty lysosomes so they can do their job properly, clear away the beta-amyloid and stop it clogging the brain. Vicious cycle In the study paper, the Yale team describes how the lysosomes build up in swollen axons or nerve fibers that contact the amyloid deposits outside the brain cells. They found that the lysosomes have abnormally high levels of beta-secretase, the enzyme that triggers the production of the toxic beta-amyloid protein. The researchers suggest the faulty lysosomes are not able to break down the enzyme because they are not fully mature. Buy Garcinia Cambogia () without prescription To become mature, they have to travel along the axons. About Carbidopa with no Rx But the beta-amyloid plaques block their ability to do this, which results in more accumulation of beta-secretase, which in turn triggers more beta-amyloid. First author Swetha Gowrishankar, a postdoctoral scientist in the lab of senior author Shawn Ferguson, assistant professor of cell biology, sums up the finding: "We think this represents a vicious circle." Put simply, to be able to do their job of eliminating the enzyme that boosts Alzheimer s plaques, the lysosomes have to be able to travel and mature. Hair Loss Cream () without Rx But their means to do this is blocked by Alzheimer s plaques. The team now plans to test in mice engineered to develop Alzheimer s whether tweaking genes to help the faulty lysosomes digest the beta-secretase protects against disease progression. Faulty lysosomes have also been implicated in other neurodegenerative diseases including Parkinson s and frontotemporal dementia, they note. Funding for the study came from the Howard Hughes Medical Institute, the Ellison Medical Foundation, the National Institutes of Health, and the Consortium for Frontotemporal Dementia Research. Meanwhile, Medical News Today recently learned how high blood sugar may contribute to Alzheimer s disease by speeding up the production of beta-amyloid. Buy Hand Cream online A study conducted in mice found that a doubling of blood glucose led to 20% higher levels of the protein. Written by Catharine Paddock PhD

Faulty cellular 'garbage disposal' implicated in Alzheimer's

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